University Hospital of Wales Paediatric Intensive Care Unit Guideline Printed on Wed 23-jul-08
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Last updated March 21, 2013 8:29 AM

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University Hospital of Wales Heath Park
Cardiff
CF14 4XW
02920 747747

Inotropes and pressors

All patients on inotropes should have

Decision on which inotropes to use, and dosing strategy will always be consultant decision.

The following inotropes are the ones used on PICU

1 microgram/kg/min = 1000 nanograms/kg/min

 

Drug

Dilution

Dose range

Rate calculations (typical starting dose in bold

 

Milrinone

 

Make a standard strength syringe of:

200micrograms in 1ml

(10mg in 50ml)

in Glucose5%,
or Sodium chloride 0.9%
or Sodium chloride 0.45%

 

250 - 750 nanogram/Kg/minute

(max dose 1microgram/Kg/minute)

For a 10mg in 50ml syringe

0.075 ml/Kg/hour = 250 nanogram/Kg/minute

0.15 ml/Kg/hour = 500 nanogram/Kg/minute

0.225 ml/Kg/hour =750 nanogram/Kg/minute

0.3 ml/Kg/hour = 1 microgram/Kg/minute

 

Adrenaline

 

 

0.3mg/Kg made up to 50ml in Gluc 5% or NS

 

 

10nanogram - 1 microgram/Kg/minute

For a 0.3mg/Kg in 50ml syringe:

1ml/hour = 100nanogram/Kg/min

10ml/hour = 1microgram/Kg/min

 

 

Noradrenaline

 

0.3mg/Kg made up to 50ml in Glucose 5%

 

10nanogram - 1 microgram/Kg/minute

For a 0.3mg/Kg in 50ml syringe:

1ml/hour = 100nanogram/Kg/min

10ml/hour = 1microgram/Kg/min

Dopamine

30 mg/kg made up to 50ml in Gluc 5% or NS

 

5 - 20 micrograms/kg/min

 

For a 30mg/kg in 50 ml syringe

1ml/hr = 10micrograms/kg/min

Dobutamine

30 mg/kg made up to 50ml in Gluc 5% or NS

 

5 - 20 micrograms/kg/min

 

For a 30mg/kg in 50 ml syringe

1ml/hr = 10micrograms/kg/min